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Hiroaki Takaya Selected Research

Lipopolysaccharides

10/2022Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis.
1/2022Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on ongoing hepatic fibrosis.
12/2021Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity.
1/2021Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway.
6/2020Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis.
3/2019Combining probiotics and an angiotensin-II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non-alcoholic steatohepatitis.
8/2017Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).

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Hiroaki Takaya Research Topics

Disease

33Fibrosis (Cirrhosis)
01/2024 - 08/2017
32Liver Cirrhosis (Hepatic Cirrhosis)
01/2024 - 02/2011
14Hepatocellular Carcinoma (Hepatoma)
11/2022 - 08/2017
9Non-alcoholic Fatty Liver Disease
11/2023 - 02/2016
8Fatty Liver
10/2022 - 11/2017
8Neoplasms (Cancer)
01/2021 - 01/2015
6Sarcopenia
08/2023 - 01/2020
5Liver Diseases (Liver Disease)
05/2023 - 01/2019
5Ascites
05/2023 - 08/2017
5Hyperammonemia
08/2022 - 12/2017
5Hepatic Encephalopathy
12/2021 - 12/2017
4Alcoholic Liver Diseases (Alcoholic Liver Disease)
12/2021 - 01/2013
4Inflammation (Inflammations)
12/2021 - 01/2013
4Infections
06/2021 - 01/2018
3Autoimmune Hepatitis
07/2023 - 06/2021
3Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis)
06/2023 - 07/2021
3Acute-On-Chronic Liver Failure
01/2023 - 05/2020
3Alcoholic Fatty Liver
10/2022 - 06/2018
3Thrombophilia
03/2022 - 05/2019
3Dysbiosis
06/2021 - 01/2018
3Muscle Cramp (Cramp)
12/2020 - 01/2019
3Hemorrhage
09/2020 - 02/2011
3Thrombosis (Thrombus)
09/2020 - 02/2011
3Insulin Resistance
08/2020 - 09/2019
2Atrophy
08/2022 - 12/2021
2Cognitive Dysfunction
06/2021 - 03/2020
2Body Weight (Weight, Body)
01/2021 - 08/2017
2Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2020 - 01/2019
2Thrombocytopenia (Thrombopenia)
09/2020 - 01/2020
2Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
07/2020 - 01/2017
2Hypertension (High Blood Pressure)
06/2020 - 11/2017
2Endotoxemia
03/2020 - 12/2017
2Carcinogenesis
03/2020 - 11/2017
2Chronic Hepatitis (Chronic Active Hepatitis)
01/2019 - 11/2018
2Hepatitis B
11/2018 - 08/2017
2Multiple Organ Failure (MODS)
02/2018 - 09/2017
2Hepatitis C
01/2018 - 08/2017
2Varicose Veins (Varicose Vein)
01/2018 - 02/2011
1Acute Kidney Injury (Acute Renal Failure)
01/2024
1COVID-19
11/2023

Drug/Important Bio-Agent (IBA)

15Biomarkers (Surrogate Marker)IBA
01/2024 - 11/2018
14EndotoxinsIBA
06/2023 - 01/2013
10von Willebrand FactorIBA
01/2024 - 09/2017
7LipopolysaccharidesIBA
10/2022 - 08/2017
6Aspartate Aminotransferases (Aspartate Transaminase)IBA
11/2023 - 09/2017
6Rifaximin (L 105)FDA Link
10/2022 - 12/2017
6CytokinesIBA
08/2022 - 01/2013
6Angiotensin II Type 1 Receptor BlockersIBA
01/2022 - 02/2016
5ZincIBA
07/2023 - 06/2021
5AntigensIBA
01/2023 - 09/2017
5Amino AcidsFDA Link
10/2022 - 10/2016
4Toll-Like Receptor 4IBA
10/2022 - 06/2021
4Choline (Choline Chloride)IBA
10/2022 - 10/2016
4Losartan (Cozaar)FDA LinkGeneric
01/2022 - 11/2017
4DiureticsIBA
01/2021 - 08/2017
3lenvatinibIBA
10/2022 - 01/2021
3CDAA (Randox)IBA
10/2022 - 10/2016
3AlbuminsIBA
10/2022 - 09/2019
3TolvaptanFDA Link
05/2022 - 08/2017
3Carbon Tetrachloride (Tetrachloromethane)IBA
12/2021 - 01/2021
3Anti-Bacterial Agents (Antibiotics)IBA
12/2021 - 03/2020
3Angiotensin Receptor AntagonistsIBA
12/2021 - 08/2020
3Tissue Inhibitor of MetalloproteinasesIBA
10/2021 - 08/2020
3Hyaluronic Acid (Hyaluronan)IBA
10/2021 - 08/2020
3Carrier Proteins (Binding Protein)IBA
10/2021 - 08/2020
3AntioxidantsIBA
06/2021 - 12/2020
3CollagenIBA
10/2020 - 08/2020
3Antiviral Agents (Antivirals)IBA
08/2020 - 01/2018
3Ursodeoxycholic Acid (Urso)FDA LinkGeneric
07/2020 - 02/2016
3Glucose (Dextrose)FDA LinkGeneric
03/2020 - 11/2017
2Urea (Carbamide)FDA LinkGeneric
11/2023 - 08/2017
2NitrogenIBA
11/2023 - 08/2017
2Hemoglobins (Hemoglobin)IBA
08/2023 - 06/2023
2BilirubinIBA
10/2022 - 10/2021
2MyostatinIBA
08/2022 - 03/2022
2EnzymesIBA
04/2022 - 06/2021
2AmmoniaIBA
03/2022 - 03/2020
2Ethanol (Ethyl Alcohol)IBA
12/2021 - 01/2021
2Branched-Chain Amino AcidsIBA
12/2021 - 09/2019
2Collagen Type III (Type III Collagen)IBA
10/2021 - 08/2020
2Triglycerides (Triacylglycerol)IBA
09/2021 - 06/2020
2Interleukin-8 (Interleukin 8)IBA
06/2021 - 09/2017
2InterleukinsIBA
06/2021 - 09/2017
2Carnitine (L-Carnitine)FDA LinkGeneric
12/2020 - 01/2019
2procollagen Type III-N-terminal peptide (PIIP)IBA
10/2020 - 08/2020
2lusutrombopagIBA
09/2020 - 01/2020
2Bile Acids and Salts (Bile Acids)IBA
06/2020 - 11/2017
2Alanine Transaminase (SGPT)IBA
04/2020 - 09/2017
2Insulin (Novolin)FDA Link
04/2020 - 09/2019
2Sorafenib (BAY 43-9006)FDA Link
12/2019 - 05/2019
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2019 - 05/2019
2ThrombospondinsIBA
05/2019 - 09/2017
2Metalloproteases (Metalloproteinases)IBA
05/2019 - 09/2017
2Toll-Like Receptors (Toll-Like Receptor)IBA
03/2019 - 01/2013
2Dipeptidyl-Peptidase IV InhibitorsIBA
01/2019 - 11/2017

Therapy/Procedure

13Therapeutics
05/2023 - 02/2011
5Oral Administration
10/2022 - 01/2018
5Drug Therapy (Chemotherapy)
12/2020 - 01/2015
3Intraperitoneal Injections
01/2021 - 01/2019
2Liver Transplantation
06/2021 - 01/2018